Phosphodiesterase-5 inhibitors: Emerging nephroprotective drugs
نویسندگان
چکیده
منابع مشابه
Phosphodiesterase-5 Inhibitors: Potential Nephroprotective Agents
Zaher Armaly1 and Zaid Abassi2,3* 1Departmentof Nephrology, EMMS Nazareth–The Nazareth Hospital, Nazareth and Galilee Medical School-Bar Ilan University, Safed, Israel 2Research Unit, Rambam Health Care Campus Haifa, Israel 3Department of Physiology, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel *Corresponding author: Zaid Abassi, Department of Physiology...
متن کاملPhosphodiesterase-5 inhibitors in the management of cancer
Selective phosphodiesterase type-5 (PDE5) inhibitors such as sildenafil, vardenafil and tadalafil are commonly used first-line therapy for erectile dysfunction (ED). The safety and high tolerability of these drugs has garnered substantial interest among researchers to investigate further beneficial nonerectogenic uses for such drugs. PDE5 expression has shown to be increased in several human ma...
متن کاملRoles of sildenafil in enhancing drug sensitivity in cancer.
The phenomenon of multidrug resistance (MDR) has decreased the hope for successful cancer chemotherapy. The ATP-binding cassette (ABC) transporter superfamily is the largest transmembrane family. The overexpression of ABC transporters is a major determinant of MDR in cancer cells both in vitro and in vivo. Unfortunately, until recently, most of the strategies used to surmount ABC-transporter-me...
متن کاملOptimization of sexual function outcome after radical prostatectomy using phosphodiesterase type 5 inhibitors.
Erectile dysfunction after radical prostatectomy is a major complication affecting postoperative quality of life. For early recovery from postoperative erectile dysfunction, attention has focused on penile rehabilitation using vacuum devices, prostaglandin E1 injection into the corpus cavernosum of the penis or transurethral administration, and oral drugs such as phosphodiesterase type 5 inhibi...
متن کاملPharmacogenomics and Pharmacoproteomics Studies of Phosphodiesterase-5 (PDE5) Inhibitors and Paclitaxel Albumin-Stabilized Nanoparticles as Sandwiched Anti-Cancer Nano Drugs between Two DNA/RNA Molecules of Human Cancer Cells
One of the most important goals in the medicine, pharmacology, pharmaceutical, physiological, clinical, biological, medical and medicinal sciences, biochemistry, pharmacogenomics and pharmacoproteomics of anti-cancer Nano drugs such as phosphodiesterase-5 (PDE5) inhibitors and paclitaxel albuminstabilized nanoparticles is the treatment. The present methods and techniques of Nano-structuring ant...
متن کامل